About Us
Dr. Sivo designed and developed a novel treatment system for the delivery of electromagnetic fields to various types of biologic cells, organ tissues and animal tumors. His research applications are specifically directed toward the study of electromagnetic field affects upon human cancer cells, more specifically pancreatic cancer cells and treatment of tumors in mice. By utilizing this novel electromagnetic field exposure system, Dr. Sivo has studied the growth, survival rate, and death rate of human pancreatic cancer cells in both cultured cells as well as mouse-related tumor cells. Dr. Sivo has recently established a working collaboration with Dr. Frank Barnes at the University of Colorado to further develop this technology through animal studies.
Dr. Sivo was involved in several cancer-related research projects during a position he held as a Postdoctoral Research Fellow and Visiting Scientist at Columbia University, College of Physicians and Surgeons. These projects included analysis of a unique cancer-selective programmed cell death-inducing cytokine gene, the development of a novel approach for cloning differentially expressed cancer-related genes, and the study of methylation in regulating gene expression in certain cancer cell types. Dr. Sivo was also involved in a collaborative research project at Duke University Department of Pathology, whereby he investigated the affects of plasma membrane H+-linked monocarboxylate transporter inhibitors on intracellular pH, in the context of a potential therapeutic target for high-risk neuroblastoma. This form of therapy is specifically intended for use in childhood-related cancers.
Selected Peer-Reviewed Publications:
1). Huang E. Y.,M.T. Madireddi, R.V. Gopalkrishnan, M. Leszczyniecka, Z.-z. Su, I.V. Lebedeva, D.-c. Kang, H. Jiang, J.J. Lin, D. Alexandre, Y. Chen, N. Vozhilla, M.X. Mei, K.R. Christiansen, F. Sivo, N.I. Goldstein, A.B. Mhashilkar, S. Chada, E. Huberman, S. Pestka and Paul Fisher. Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties. Oncogene 20: 7051-7063, 2001
2). Gopalkrishnan, R.V., Z.-z. Su, D.-c. Kang, D. Sarker, M. Sauane, M. Leszczyniecka, I.V. Lebedeva, F. Sivo, N.I. Goldstein and P.B. Fisher. DISH- Differentiation induction subtraction hybridization. In: Analysing Gene Expression, Lorkowski, S. and Cullen, P. (Eds.) Wiley-VCH Verlag GmbH, Germany, Ch. 3.2.4.1, pg. 178-185, 2002
3). Fang, J, Morowitz MJ, Wang Q, Zhao H, Sivo F, Maris JM, Wahl ML. (2006), The H+-linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic target for High-Risk Neuroblastoma. Mol Pharmacol 70, 2108-2115, 2006
Dr. Barnes, Distinguished Professor of Electrical Computer and Energy Engineering at the University of Colorado at Boulder, has spent his entire career in the field of electrical engineering and physics, both as a teaching professor as well as an inventor - building and commercializing innovative products for the medical and scientific community. Dr. Barnes brings his expertise in electrical engineering to the company and has teamed-up with Dr. Sivo in this combined effort to bring a novel form of cancer treatment to clinical perfection.
Dr. Barnes received his B.S. from Princeton University in electrical engineering in 1954, his M.S. Engineer and Ph.D from Stanford University in 1955, 1956, and 1958. He joined the University of Colorado in 1959. He has served as Chair of the Department of Electrical and Computer Engineering, Acting Dean of Engineering and was a co-founder of the interdisciplinary program in telecommunications. He was appointed a Distinguished Professor in 1997. He was elected to the National Academy of Engineering in 2001, and received the Gordon Prize 2004 for innovations in Engineering Education from the National Academy. He is a fellow of IEEE, AAAS, and the ICF. He has worked on a wide variety of research topics including laser, super conductors, and the effects of electric and magnetic fields on biology. His work on electric and magnetic field effects on biology has included both experiments of the effects of RF and microwaves on neutrophils and theory on the mechanisms of interactions between the fields and the biology. He has served as president of the Bioelectromagnetics Society and is a co-editor of the CRC Handbook of Biological Effects of Electric and Magnetic Fields.
Dr. Barnes has been working on the effects of electrical and magnetic fields on biological systems for more than 40 years beginning with work on physics behind laser surgery and RF field effects on tissue. Much of the work of him and his students has been directed toward understanding how low levels of these fields can affect biological systems. The work has resulted in numerous scientific papers and book chapters.
Dr. Barnes' curriculum vitae may be viewed here.
